stroke
Conditions
Interventions
preconditioning group:The patients received cTBS pretreatment stimulation, and 10 minutes after cTBS stimulation, they received iTBS. The cTBS stimulation parameters were 50Hz in the plexus and 5Hz in
iTBS Group:The intervention targets and stimulation parameters of the sham stimulus were consistent with those of the real stimulus. A special sham stimulation coil was used during the intervention, w
Routine rehabilitation group:Sham stimulation was used in both cTBS and iTBS, and the intervention targets and stimulation parameters of the sham stimulation were consistent with those of the real sti
Sponsors
Peking University Shougang Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meets the 2019 diagnosis criteria for stroke set by the Cerebrovascular Group of the Chinese Medical Association Neurology Society, and confirmed by cranial CT and/or MRI as subcortical hemorrhagic stroke or subcortical ischemic stroke; 2. First onset, affected hemisphere is unilateral, with unilateral limb motor dysfunction; 3. Onset time: 2 weeks to 3 months after stroke (subacute phase); 4. Age: 45-75 years; 5. Lower limb Brunnstrom stage III~IV; 6. Conscious, able to cooperate with physical examination, without severe cognitive dysfunction; 7. Standing balance >= level 1, able to walk at least 10 meters with assistance; 8. Patient voluntarily participates and cooperates in completing cTBS, iTBS, or iTBS treatment, and signs informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of metal foreign bodies in the skull, a cardiac pacemaker, or other implanted electronic devices (including pulse generators, drug pumps), cochlear implants, history of cranial surgery, or skull defects; 2. High risk of noise-induced hearing loss (including receiving ototoxic drug treatment and exposure to solvents), or symptoms of auditory hypersensitivity; 3. Pregnant or breastfeeding women; 4. History of epilepsy, other neurological diseases (such as Parkinson's disease, multiple sclerosis), severe cognitive/communication/emotional disorders preventing cooperation with assessment; 5. Modified Ashworth score >3 in the affected lower limb, severe pain affecting mobility, lower limb injury unrelated to stroke (e.g., recent fracture, joint replacement surgery 160/100mmHg), severe cardiopulmonary insufficiency, liver/kidney/lung failure, increased intracranial pressure; 7. Received rTMS, tDCS, or other neuromodulation treatments within 3 months prior to enrollment; 8. Other conditions deemed unsuitable for participation in this study by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment of Lower Extremity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Berg Balance Scale;Modified Barthel Index;10-meter maximum Walking Speed;walking speed;walking frequency;walking stride;gait cycle;Percentage of double support phase;Motor Evoked Potential;Resting Motor Threshold;Central Motor Conduction Time; | — |
Countries
China
Contacts
Public ContactWu Liang
Peking University Shougang Hospital
Outcome results
None listed