Colorectal cancer
Conditions
Interventions
Colorectal cancer (CRC) group:None
Intervention group:Histidine capsules administered orally
Healthy control group:None
Sponsors
Punan Hospital,Pudong New District, Shanghai
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–80 years, regardless of sex; 2. Body mass index (BMI) >=18.5; 3. NRS-2002 score <3; 4. Patients diagnosed with stage II or higher colorectal cancer who require pharmacological intervention; 5. Able to take oral medication; 6. Willing to participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Participation in another interventional clinical trial (including drugs, nutritional supplements, or medical devices) within 4 weeks prior to enrollment; 2. Presence of ascites, severe diarrhea, intractable vomiting, severe malabsorption syndrome, paralysis, mechanical intestinal obstruction, or active gastrointestinal bleeding; 3. Known allergy to any component of the study product; 4. Current use of other nutritional supplements that may affect the validity of the study results; 5. Positive pregnancy test at baseline, breastfeeding women, or women of childbearing potential who are pregnant; 6. Presence of cognitive impairment or psychiatric disorders that prevent understanding of the study procedures; 7. Any other condition that, in the investigator’s judgment, makes the participant unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood immune cell function;Serum histidine level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor volume; | — |
Countries
China
Contacts
Public ContactChen Fengyuan
Punan Hospital,Pudong New District, Shanghai
Outcome results
None listed