Low Cardiac Output Syndrome
Conditions
Interventions
Hydrocortisone group:The hydrocortisone group will receive 200 mg/day via continuous intravenous infusion over 24 hours for 7 consecutive days or until transfer out of the CICU, whichever occurs first
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 18 years; 2. Post-cardiac surgery low cardiac output syndrome (LCOS): patients who have undergone cardiac surgery and meet any of the following criteria: (1) use of mechanical circulatory support (MCS); (2) cardiac index (CI) < 2.0 L/min/m² on two consecutive measurements; (3) concurrent use of two or more inotropic agents for more than 24 hours, with at least one CI measurement < 2.0 L/min/m²; (4) use of two or more inotropic agents for more than 24 hours due to low cardiac output. 3. Signed informed consent by the patient or their legally authorized representative.
Exclusion criteria
Exclusion criteria: 1. LCOS diagnosed for more than 24 hours; 2. Sepsis present at enrollment; 3. Received corticosteroid treatment within 4 weeks prior to enrollment; 4. Received etomidate treatment prior to enrollment; 5. Immunosuppression; 6. Hypersensitivity to hydrocortisone; 7. Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vasopressor-free days in both groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; ICU mortality and in-hospital mortality; ICU length of stay and total hospital length of stay; | — |
Countries
China
Contacts
Public ContactJun Shao
Northern Jiangsu Peopl's Hospital
Outcome results
None listed