Postoperative pain
Conditions
Interventions
Sufentanil group:Postoperative patient-controlled intravenous analgesic pump(Sufentanil 80µg+0.9%NS=80ml, concentration 1µg/ml, PCIA dose 3µg, lock time 30min).
Tegiletidine group:Postoperative patient-controlled intravenous analgesia pump (tegiletidine 4mg+0.9%NS=80ml, concentration 0.05mg/ml, PCIA dose 0.15mg, lock time 30min)
Sponsors
Foshan Nanhai District People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Elective mastectomy under general anesthesia. 2. Aged 18~65. 3. Female. 4. BMI 18~25 kg/m². 5. ASA physical status from 1 to 3. 6. Signing the informed consent form for the trial.
Exclusion criteria
Exclusion criteria: 1. Long-term use of opioid drugs or addiction, or allergy to opioids or any component of this product; 2. Emergency surgery; 3. Preoperative psychiatric disorders or severe anxiety; 4. Consciousness disorders, severe visual, auditory, or speech communication impairments; 5. Severe liver and kidney dysfunction and other systemic diseases; 6. Allergy to drugs used during anesthesia; 7. Pregnant or breastfeeding patients; 8. Patients with acute or severe bronchial asthma; 9. Known or suspected gastrointestinal obstruction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery-15(QoR-15); | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pain intensity:VAS;The number of total presses of PCA within postoperative 48 hours.; | — |
Countries
China
Contacts
Public ContactPing Mo
Foshan Nanhai District People's Hospital
Outcome results
None listed