Neurodegenerative diseases
Conditions
Interventions
Gold Standard:PD: 2015 MDS Clinical Diagnostic Criteria for Parkinson's Disease
MSA: Third Consensus Statement on the Diagnosis of Multiple System Atrophy
PSP: 2017 MDS Clinical Diagnostic Criteria for Progressive Supranuclear Palsy
DLB: Fourth Consensus Report of the DLB Consortium
CBD: 2013 Criteria for Corticobasal Degeneration
FTLD: 2011 International Consensus Criteria for Frontotemporal Lobar Degeneration
Index test:Perform dual tracer imaging of polyparaminergic (11C-CFT and 18FP-CIT) and glucose metabolism (18F-FDG)
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 75 years, regardless of gender; 2.Presenting with Parkinsonian symptoms at initial visit, suspected of having a Parkinsonian disorder; 3.Availability of clinical follow-up diagnostic records for at least one year; 4.Clinical diagnosis meeting established diagnostic criteria (PD: 2015 MDS Clinical Diagnostic Criteria for Parkinson's Disease; MSA: Third Consensus Statement on the Diagnosis of Multiple System Atrophy; PSP: 2017 MDS Clinical Diagnostic Criteria for Progressive Supranuclear Palsy; DLB: Fourth Consensus Report of the DLB Consortium; CBD: 2013 Criteria for Corticobasal Degeneration; FTLD: 2011 International Consensus Criteria for Frontotemporal Lobar Degeneration). All diagnoses were reviewed and confirmed by two corresponding neurological specialists from Huashan Hospital. Cases with diagnostic discrepancies were resolved through discussion by the Movement Disorders Specialty Group of Huashan Hospital's Neurology Department. 5.Availability of both dopaminergic and glucose metabolism dual-tracer PET imaging with accessible images.
Exclusion criteria
Exclusion criteria: 1.Unclear PET images or significant motion artifacts on MRI images; 2.Basal ganglia and/or brainstem infarction or other structural abnormalities on MRI images.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic Confidence;Standard uptake value ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Accuracy; | — |
Countries
China
Contacts
Public ContactWang Jian
Huashan Hospital, Fudan University
Outcome results
None listed