Obesity
Conditions
Interventions
Real iTBS + CST group:Real intermittent theta-burst stimulation (iTBS) over the left dorsolateral prefrontal cortex (l-dlPFC
F3, 10–20 EEG system) using a Magstim Rapid2 stimulator with a 70-mm figure-of-eight coil. Stimulation intensity: 80% resting motor threshold (RMT
determined from right APB). iTBS pattern: bursts of 3 pulses at 50 Hz repeated at 5 Hz
2-s trains
20 trains
inter-train interval 8 s
total 600 pulses
total duration 192 s. Schedule: 2 sessions/week for 4 weeks (8 sessions total). Immediately after each iTBS session, participants complete a ~15-min Cognitive Strategy Training (CST) module consisting
Sham iTBS + CST group:Sham iTBS combined with Cognitive Strategy Training (CST). Sham stimulation mimics the active iTBS procedure in session timing, number of trains/bursts, stimulation sound, partic
25 high-calorie and 25 low-calorie food images) with identical instructions and rating procedures as the real group.
Sponsors
Wuhan Sports University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.adults aged between 18 and 60 years; 2. right-handed; 3. body mass index (BMI) >= 28 kg/m^2, defining obesity according to Chinese criteria; 4. able to understand study procedures and provide written informed consent; 5. absence of any known major cardiovascular diseases; 6. no current or history of clinically diagnosed eating disorders; 7. no contraindications to repetitive transcranial magnetic stimulation (rTMS)/intermittent theta-burst stimulation (iTBS), as per standard safety screening.
Exclusion criteria
Exclusion criteria: 1. any known history of neurological disorders (e.g., epilepsy, stroke, brain tumor) or major psychiatric disorders; 2. current use of psychoactive medications; 3. presence of metallic or electronic implants in the head or neck region (excluding dental fillings); 4. pregnancy, lactation, or planned pregnancy during the study period; 5. chronic or frequent headaches/migraines; 6. significant, uncorrected hearing impairment; 7. personal or first-degree family history of epilepsy; 8. any other condition deemed a standard contraindication for rTMS by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dietary self-control failure rate;Choice proportion (%Yes);Health decision weights;Taste decision weights;Task-evoked HbO in l-dlPFC during decision block (fNIRS GLM ß);Task-evoked HbO in l-OFC during decision block (fNIRS GLM ß);Body mass index (BMI); | — |
Countries
China
Contacts
Public ContactXia Xu
Wuhan Sports University
Outcome results
None listed