Acute Gouty Arthritis
Conditions
Interventions
Trial Group:Wushen Decoction (Honeysuckle 20g, Achyranthes root 20g, Poria 30g, Plantain Seed 20g, Purple Viola 20g), one dose daily, warm oral administration after breakfast and dinner
Control Group:Colchicine tablets (initial dose 1mg, increase by 0.5mg after 1 hour, then 0.5mg twice daily)
Sponsors
Binzhou Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18 and 75 years, inclusive; 2. Fulfill the ACR/EULAR classification criteria for gouty arthritis; 3. The current acute episode has lasted less than 48 hours; 4. Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Known allergy to any components of Wushen Decoction, colchicine tablets, or other study drugs; 2. Concurrent joint diseases such as rheumatoid arthritis, osteoarthritis, or traumatic arthropathy; 3. Local skin breakdown over the affected joint; 4. Severe hepatic or renal impairment (eGFR 3 × upper limit of normal), or poorly controlled diabetes mellitus; 5. Comorbid severe primary diseases involving the cardiovascular, digestive, urinary, or hematopoietic systems, or a history of peptic ulcer with bleeding or perforation; 6. Mental or psychological disorders that may affect compliance; 7. Planned pregnancy within 6 months, or currently pregnant or lactating; 8. Other conditions that may lead to dropout, such as inability to guarantee scheduled follow-up visits; 9. Current participation in other related clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin-6;Tumor Necrosis Factor-alpha;C-reactive protein;Erythrocyte Sedimentation Rate;Serum uric acid level; | — |
Countries
China
Contacts
Public ContactFeng Chaoli
Binzhou Hospital of Traditional Chinese Medicine
Outcome results
None listed