Brain-heart axis
Conditions
Interventions
Observation group:None
Sponsors
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years and < 80 years; 2. Undergoing elective abdominal major surgery under general anesthesia; 3. ASA classification I - III (American Society of Anesthesiologists classification); 4. Radial artery puncture and catheterization were performed before the operation; during the operation, electrocardiogram, electroencephalogram, and invasive arterial blood pressure monitoring were routinely performed as needed for the surgery.
Exclusion criteria
Exclusion criteria: 1. Significant abnormalities in preoperative electrocardiogram or cardiac ultrasound results, or placement of a pacemaker; presence of neurological disorders (mental disorders, history of epilepsy, history of stroke, traumatic brain injury); 2. Use of antiarrhythmic drugs before surgery; body mass index (BMI) > 30 kg/m^2; 3. Unable to communicate preoperatively due to coma, severe dementia, or speech disorders; 4. Uncontrolled severe hypertension before surgery (ward baseline blood pressure SBP > 180 mmHg or DBP > 110 mmHg); 5. Severe liver dysfunction (Child-Pugh class C); severe renal dysfunction (receiving dialysis preoperatively); ASA classification = V or expected survival = 24 hours; 6. Presence of unstable cardiovascular conditions (acute coronary syndrome, decompensated heart failure, severe arrhythmia, severe valvular disease); 7. Planned craniocerebral surgery, organ transplant surgery, or vascular surgery; 8. Presence of preoperative sepsis; 9. Presence of respiratory failure.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram waveform;Electrocardiogram waveform;Invasive arterial blood pressure;Anesthesia depth index;Center frequency;Duration of inhibition;Postoperative early cognitive function score;Preoperative cognitive function score; | — |
Primary
| Measure | Time frame |
|---|---|
| Brain-heart coupling strength (GC value) and directional changes; | — |
Countries
China
Contacts
Public ContactLei Qian
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
Outcome results
None listed