None
Conditions
Interventions
Control group:Sufentanyl for postoperative analgesia
Experimental group:Oliceridine for postoperative analgesia
Sponsors
The First Affiliated Hospital of Shihezi University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 60 and 80 years old 2. ASA grade I-III, without major systemic disease history 3. Body Mass Index (BMI) ranging from 18.5 to 28 kg/m^2 4. Elderly patients undergoing elective lumbar surgery under general anesthesia and sedation 5. Able to cooperate with perioperative sleep quality assessment and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Long-term use of opioid drugs before the operation; 3. Previous history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis; 4. Unable to communicate before the operation due to coma, severe dementia or language disorders; 5. Severe heart disease (Class 3 or above cardiac function), chronic obstructive pulmonary disease or pulmonary heart disease; 6. Severe liver function impairment (Child-Pugh grade C); 7. Severe kidney function impairment (requiring renal replacement therapy); 8. QT prolongation shown on the preoperative electrocardiogram; 9. History of gastrointestinal dysfunction before the operation; 10. Allergic to oxybenonium or other anesthetic drugs; 11. Asthmatic patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure the highest value of the I-FEED score continuously for four days after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay score;Visual analogue pain rating;First deflation time, defecation time;The first time of tolerance for oral feeding;Postoperative hospital stay duration; | — |
Countries
China
Contacts
Public ContactShi Chongzhi
The First Affiliated Hospital of Shihezi University
Outcome results
None listed