Postopertaive Sleep Disorders
Conditions
Interventions
Part 1: SD Group:None
Part 1: Non-SD Group:None
Part 2: S Group:Normal saline 0.25mg/kg (IV bolus at induction) + 0.125mg/kg/h (IV infusion until end of surgery)
Part 2: E Group:Esketamine 0.25mg/kg (IV bolus at induction) + 0.125mg/kg/h (IV infusion until end of surgery)
Sponsors
The Second Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=60 years old; 2. Patients scheduled for endoscopic surgery; 3. ASA classification I-III; 4. NYHA Grade I-II; 5. BMI: 18-28kg/m^2; 6. Sign the informed consent form for this study.
Exclusion criteria
Exclusion criteria: 1. Preoperative sleep disorder (PSQI>7); 2. Taking or taking psychotropic drugs or sedatives in the past; 3. People with severe heart, lung, liver and kidney insufficiency or neuropsychiatric diseases; 4. Unwilling to participate, unable to communicate and unable to cooperate with the research; 5. Patients with severe hypertension before surgery; 6. Patients who are allergic to acetamine. (Standard 5 and Standard 6 are for patients in the second part of the experiment.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative sleep disturbance incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety and depression scores;Pain score;Quality of postoperative recovery;Perioperative information (vital signs, medication use, surgery duration, etc.); | — |
Countries
China
Contacts
Public ContactGao Jiahong
The Second Affiliated Hospital of Shantou University Medical College
Outcome results
None listed