Acute pancreatitis
Conditions
Interventions
Intervention group:After admission, a standard-dose proton pump inhibitor was administered once daily for three consecutive days
Placebo group:After admission, 100ml of normal saline was administered once a day for three consecutive days
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with mild acute pancreatitis meeting the "2012 Atlanta AP Classification and Diagnostic Criteria"; 2. Onset within 48 hours (starting from persistent abdominal pain); 3. Age between 18 and 75 years old; 4. Willing to comply with the study procedures and sign the informed consent form; 5. HAPS score at admission is negative (i.e., predicted to have non-severe acute pancreatitis); Scoring criteria: no abdominal muscle tension, no rebound tenderness, normal hematocrit (male <=43%, female <=39.6%); serum creatinine level (<176.8 mmol/L).
Exclusion criteria
Exclusion criteria: 1. Patients with other severe digestive system diseases, such as gastrointestinal bleeding, peptic ulcer, perforation, acute cholecystitis, intestinal obstruction, etc., that may interfere with the evaluation of treatment effects for acute pancreatitis; 2. Patients who had severe liver and kidney dysfunction, heart failure (NYHA class III or above), pulmonary diseases (such as acute exacerbation of chronic obstructive pulmonary disease, respiratory failure, etc.), malignant tumors, or other serious underlying conditions prior to onset, which may affect prognosis or prevent tolerance to trial drugs and treatment; 3. Allergy or contraindication to proton pump inhibitors (PPI), such as allergy to PPI components or a strong tendency for severe gastrointestinal bleeding; 4. Pregnant or breastfeeding women; 5. Individuals with mental illness or cognitive impairment who cannot understand the study or cooperate with the assessments; 6. Patients who received acid suppression therapy within 72 hours before randomization; 7. Patients with biliary pancreatitis complicated by acute cholangitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Eating tolerance;The degree of abdominal pain;28-day readmission rate;Hospitalization expenses;New-onset organ failure;28-day follow-up;PAN-PROMISE scale score; | — |
Countries
China
Contacts
Public ContactLiang Xia
The First Affiliated Hospital of Nanchang University
Outcome results
None listed