Prospective memory deficits in schizophrenia spectrum disorder
Conditions
Interventions
Sham:Transcranial direct current stimulation
Active:Transcranial direct current stimulation
Sponsors
Beijing An Ding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Meeting the DSM-5 diagnostic criteria for schizophrenia spectrum disorders; 2.Aged 18–45 years and right-handed; 3.Having at least a primary school level of education, with an IQ > 70; 4.Scoring no more than 5 on the following PANSS items: P1 (Delusions), P3 (Hallucinatory behavior), P5 (Grandiosity), P6 (Suspiciousness/Persecution), and G9 (Unusual thought content); 5.Scoring no more than 4 on PANSS item P2 (Conceptual disorganization); 6.Scoring below the normative mean on the Cambridge Prospective Memory Test; 7.Being clinically stable, with the current antipsychotic and concomitant medication regimen maintained for at least 6 weeks prior to enrollment, and antipsychotic dosage unchanged for at least 2 weeks. During the study period, the type and dosage of antipsychotic medications remained unchanged.
Exclusion criteria
Exclusion criteria: 1.Presence of a cochlear implant or other implanted metallic devices; 2.Presence of hearing impairment; 3.Pregnancy or breastfeeding; 4.History of severe neurological disorders (e.g., traumatic brain injury or central nervous system infection, brain tumors, cerebrovascular disease, epilepsy) or other serious medical conditions; 5.Marked clinical instability, including suicidal ideation or impulsive behavior; 6.History of alcohol or substance abuse or dependence within the past 6 months (excluding tea, coffee, and tobacco); 7.Use of sedative–hypnotic medications at doses exceeding lorazepam 1 mg/day or its equivalent; 8.Total daily dose of anticholinergic medications exceeding trihexyphenidyl 10 mg/day or its equivalent; 9.Receipt within the past 6 months of central nervous system stimulant treatments (e.g., methylphenidate, amphetamines, modafinil), electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), other electromagnetic stimulation therapies, or systematic cognitive training; 10.Repeated assessment with the MCCB and/or other comprehensive cognitive test batteries within the past 12 weeks (i.e., a single assessment was not an exclusion); 11.Inability or unwillingness to comply with study assessments and interventions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy in the cue–nonfocal prospective memory eye-tracking task;CAMPROMPT; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function;psychotic symptoms;cue–nonfocal prospective memory eye-tracking task;Brain image data;EEG data; | — |
Countries
China
Contacts
Public ContactChuanyue Wang
Beijing An Ding Hospital, Capital Medical University
Outcome results
None listed