Severe cerebrovascular diseases (such as massive cerebral hemorrhage, severe cerebral infarction), severe brain and spinal cord injuries, central nervous system infections, status epilepticus, perioperative patients requiring life support and neurological function monitoring, as well as rapidly progressing and complex difficult-to-treat neurological diseases with unclear causes
Conditions
Interventions
Control group:Bilateral phrenic nerve shame magnetic stimulation
Experimental Group:Bilateral phrenic nerve magnetic stimulation
Sponsors
The First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old; 2.Clinically or radiologically confirmed, meeting the diagnostic criteria for any of the following diseases: ischemic stroke, intracranial hemorrhage, hypoxic-ischemic encephalopathy, traumatic brain injury, subarachnoid aneurysmal hemorrhage, metabolic encephalopathy, central nervous system infection, encephalitis. 3.Tracheal intubation and mechanical ventilation support have been received for more than 24 hours, and the total mechanical ventilation time is expected to be at least 48 hours; 4.The patient himself/herself or his/her legal representative voluntarily participated in this study and signed written informed consent;
Exclusion criteria
Exclusion criteria: 1.Pre-existing motor neuron disease or muscle disorders (such as amyotrophic lateral sclerosis, myasthenia gravis, etc.) may affect the assessment of diaphragm function; 2.There is phrenic nerve palsy or any condition that may limit the movement of the diaphragm (such as intra-abdominal hypertension, massive ascites, body mass index BMI > 35); 3.Those who have been diagnosed with or are highly suspected of having spinal cord injury and are contraindicated for spinal cord weight-bearing; 4.There is a history of severe underlying lung, thoracic or abdominal diseases; 5.There is a history of severe underlying lung, thoracic or abdominal diseases; 6.Cardiac pacemakers, implantable cardioverter defibrillators, or other metal implants (in the neck area) implanted in the body are contraindicated for magnetic stimulation; 7.Drugs that may significantly lower the threshold for epileptic seizures are being used; 8.Drugs that may significantly lower the threshold for epileptic seizures are being used; 9.Pregnancy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragmatic excursion; | — |
Secondary
| Measure | Time frame |
|---|---|
| The thickness and thickening fraction of the intercostal muscles beside the sternum;Air sac pressure during calm breathing and coughing;The thickness of the abdominal muscles and their thickening fraction when coughing;Diaphragm thickening fraction;Bladder pressure during calm breathing and coughing (Simple water Jet Method); | — |
Countries
China
Contacts
Public ContactNi Jun
The First Affiliated Hospital of Fujian Medical University
Outcome results
None listed