Osteoarthritis,spondyloarthritis
Conditions
Interventions
Healthy Controls:None
Surgical Patients:None
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Normal Healthy Adults (1) Voluntarily sign the informed consent form; (2) Age 18 =3 months) persistent joint pain, joint swelling, morning stiffness, or limited mobility; (7) Physical examination revealed no obvious joint tenderness, swelling, deformity, or significantly limited range of motion; (8) No diagnosed systemic inflammatory diseases or autoimmune diseases, including but not limited to: systemic lupus erythematosus, ankylosing spondylitis, psoriatic arthritis, vasculitis, inflammatory bowel disease-associated arthropathy, etc.; (9) No history of acute systemic infection or febrile illness in the recent period (e.g., within the last 3 months); (10) If joint imaging examinations (X-ray, MRI, or ultrasound) were performed during routine physical exams or clinical checks, no pathological changes clearly related to bone and joint diseases were found; (11) If inflammation-related indicators (such as CRP, ESR) were tested, results were within normal reference ranges or showed no clinically significant abnormalities; (12) No long-term use (continuous >=2 weeks) of drugs affecting bone, joint, or immune status in the recent period, including: glucocorticoids, immunosuppressants, biologics, disease-modifying antirheumatic drugs (DMARDs), etc. 2. Patients (1) Voluntarily sign the informed consent form; (2) Age 18 =3 months) persistent joint pain, joint swelling, morning stiffness, or limited mobility; (8) No diagnosed systemic inflammatory diseases or autoimmune diseases, including but not limited to: systemic lupus erythematosus, ankylosing spondylitis, psoriatic arthritis, vasculitis, inflammatory bowel disease-associated arthropathy, etc.; (9) No history of acute systemic infection or febrile illness in the recent period (e.g., within the last 3 months); (10) No long-term use (continuous >=2 weeks) of drugs affecting bone, joint, or immune status in the recent period, including: glucocorticoids, immunosuppressants, biologics, disease-modifying antirheumatic drugs (DMARDs), etc.
Exclusion criteria
Exclusion criteria: 1. Normal Healthy Adults (1) Previous diagnosis of bone and joint diseases such as OA, RA, SpA, or other systemic autoimmune diseases; (2) Clear history of joint trauma or joint surgery; (3) Comorbid severe chronic systemic diseases; (4) Deemed unsuitable for participation in this study by the investigator. 2. Patients (1) Previous diagnosis of bone and joint diseases such as OA, RA, SpA, or other systemic autoimmune diseases; (2) Comorbid severe chronic systemic diseases; (3) Deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnetic resonance imaging of sacroiliac, spinal, and knee joints; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bath Ankylosing Spondylitis Metrology Index (BASMI) Score;Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)Score;Indicators of streptococcal infection;Terms and Conditions for Using the 36-Item Short Form Survey(SF-36)(Physical Functioning (PF)?Mental Health (MH) ); | — |
Countries
China
Contacts
Public ContactXiao Jun
Southern Medical University Southern Hospital
Outcome results
None listed