Dry age-related macular degeneration
Conditions
Interventions
Trial Group:Qi Huang Granules (10g per bag, composed of Lycium barbarum, Cornus officinalis, Leonurus heterophyllus, Salvia miltiorrhiza, Platycodon grandiflorum, Bupleurum chinense, etc.), 1 bag thre
Control Group:Lutein Tablets (10mg lutein per tablet), 1 tablet once daily orally, continuous treatment for 3 months
Sponsors
Guangdong Second Traditional Chinese Medicine Hospital(Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine)
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 50–79 years, regardless of gender; 2. Meet the diagnostic criteria of dry AMD; 3. Meet the TCM syndrome criteria of liver-kidney yin deficiency and phlegm-stasis interminglement for dry AMD. 4. Patients without prior anti-VEGF, laser or surgical treatment; 5. Patients with good compliance who can cooperate with ophthalmic examinations, complete standardized treatment, voluntarily provide clinical data, and provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1. With concurrent wet AMD, diabetic retinopathy, glaucoma or other vision-affecting ocular fundus diseases; 2. Received anti-VEGF drugs, glucocorticoids, immunosuppressants or other Chinese medicines for AMD within the recent 3 months. 3. Abnormal hepatic and renal function: ALT/AST > 1.5 × ULN, serum creatinine > ULN; 4. Allergy to Qihuang Granules or lutein. 5. Not conforming to the TCM syndrome pattern of Liver-Kidney Yin Deficiency combined with Phlegm-Stasis Interminglement. 6. Those with cognitive impairment, mental illness, or other conditions that prevent them from cooperating in follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Retinal vascular flow density;Hemorheological parameters;NEI VFQ-25;Best-corrected visual acuity;Serum levels of the inflammatory cytokines IL?1ß, IL?18, and NLRP3;Multi-spatial frequency contrast sensitivity function;Choroidal blood flow density and thickness;Amsler grid;Drusen volume; | — |
Countries
China
Contacts
Public ContactWang Yan
Guangdong Second Traditional Chinese Medicine Hospital(Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine)
Outcome results
None listed