Early postoperative pulmonary dysfunction
Conditions
Interventions
Double-lumen tube group (Control group):Conventional double-lumen tube bronchial intubation followed by mechanical ventilation via anesthesia machine. During bilateral lung ventilation: tidal volume 6
during single-lung ventilation: tidal volume 4–6 mL/kg, respiratory rate 15–18 breaths/min, inspired oxygen concentration 100%. Arterial blood gas analysis performed 15 minutes after extubation while
LMA group (Trial Group 1):After anesthesia induction, a laryngeal mask airway (LMA) was inserted and spontaneous breathing was maintained. Inspired oxygen concentration 100%, oxygen flow 2.0–5.0 L/min
Nasal high-flow oxygen group (Trial Group 2):After anesthesia induction, high-flow nasal oxygen was administered. Arterial blood gas analysis performed 15 minutes after emergence while breathing room
Sponsors
Peking University People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective thoracoscopic lung wedge resection; 2. Aged 18 to 64 years; 3. Body mass index (BMI) = 26 kg/m^2; 4. American Society of Anesthesiologists (ASA) classification ?–?; 5. Abstained from smoking for more than 2 weeks; 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a clear diagnosis of severe airway hyperresponsiveness before surgery; 2. Patients with preoperative pulmonary infection; 3. Patients with severe chest deformity resulting from recent acute chest trauma or prior remote trauma; 4. Patients allergic to local anesthetics; 5. Patients with severe dysfunction of vital organs (e.g., heart, lungs, liver, kidneys) or with hematological diseases; 6. Patients with a prior history of neurological or psychiatric disorders; 7. Patients who withdraw during the study or are unable to cooperate fully; 8. Any patient judged by the investigator to be unsuitable for participation in this study; 9. Patients who have participated in other clinical trials related to pulmonary function within the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of change in the oxygenation index (?OI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain scores;Anesthesia duration;Surgical duration;Awakening time;Blood loss;Total fluid infusion volume;Anesthetic drug consumption;Vasoactive drug dose;Postoperative throat discomfort;Patient satisfaction;Surgeon satisfaction;Postoperative length of hospital stay;Medical costs;Incidence of postoperative pulmonary complications; | — |
Countries
China
Contacts
Public ContactLiang Hansheng
Peking University People’s Hospital
Outcome results
None listed