Traumatic brain injury
Conditions
Interventions
Control group (moderate to severe TBI):Children with moderate to severe TBI received treatments such as monitoring, control of intracranial pressure, analgesia and sedation, and surgery when necessary
MLT group (moderate to severe TBI):Children with moderate to severe TBI received MLT orally or via nasogastric tube (1–2 mg per dose, once daily) for one week in addition to conventional treatment.
Mild TBI group:Without any intervention, only the serum melatonin expression levels of the pediatric patients were detected.
Sponsors
Xuzhou Children's Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Has a clear history of brain trauma, confirmed by head CT scan or magnetic resonance imaging (MRI); 2. Age 2-18 years old; 3. Glasgow Coma Scale (GCS) <= 12 points; 4. Time from injury to admission < 24 hours; 5. No previous neurological diseases or brain trauma; 6. No other severe organic lesions in other organs; 7. Parental informed consent of the child is obtained.
Exclusion criteria
Exclusion criteria: 1. Combined central nervous system infection; 2. Need for fasting due to digestive system diseases or trauma; 3. Having underlying diseases such as autoimmune diseases, blood diseases, endocrine diseases or malignant tumors; 4. Parents refuse to participate or withdraw from the study halfway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow Coma Scale;GOS Prognostic Score;Melatonin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuron-specific enolase;S100B Protein;Glial Fibrillary Acidic Protein;Ubiquitin C-Terminal Hydrolase L1;Malondialdehyde;Superoxide Dismutase;8-iso-Prostaglandin;Tumor Necrosis Factor-alpha;Interleukin-6;Interleukin-1 beta;Brain-Derived Neurotrophic Factor; | — |
Countries
China
Contacts
Public ContactZhu Lei
Xuzhou Children's Hospital
Outcome results
None listed