including total hysterectomy, myomectomy, ovarian cystectomy, tubal surgery, etc
Conditions
Interventions
VC group :Volume-controlled ventilation (VCV) was adopted. The tidal volume (VT) was set at 6–8 mL/kg based on ideal body weight, which was calculated as height (cm) minus 105. PEEP was maintained at
if peak airway pressure exceeded this limit, tidal volume or respiratory rate was adjusted promptly.
PC group:Pressure-controlled ventilation (PCV) was adopted. The initial pressure control level was set to the pressure that could achieve a tidal volume (VT) of 6–8 mL/kg (based on ideal body weight),
VC-AF Group:Volume-controlled automatic flow ventilation (VC-AF) was adopted. The target tidal volume (VT) was set at 6–8 mL/kg based on ideal body weight. PEEP was set at 5 cmH2O with an inspiratory-
Sponsors
General Hospital of Ningxia Medical Univeristy
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18–65 years, female gender; (2) Scheduled for elective gynecological laparoscopic surgery, including total hysterectomy, myomectomy, ovarian cystectomy, tubal surgery, etc., with a definite surgical procedure; (3) American Society of Anesthesiologists (ASA) physical status classification I–III, without severe anesthetic contraindications; (4) Body mass index (BMI) ranging from 18 to 30 kg/m², without extreme obesity or emaciation, to avoid the influence of body weight on pulmonary function and ventilation parameters; (5) Preoperative pulmonary function was basically normal, without obvious ventilatory or gas exchange dysfunction; (6) Patients and their families provided informed consent, voluntarily participated in this study, and signed the informed consent form; (7) Able to cooperate with intraoperative monitoring and postoperative follow-up, with no history of cognitive dysfunction or psychiatric disorders.
Exclusion criteria
Exclusion criteria: (1) History of severe cardiopulmonary diseases (such as coronary heart disease, heart failure, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, etc.); (2) Presence of difficult airway (such as Mallampati classification = grade III, limited cervical spine mobility, difficulty opening mouth, etc.), or contraindications to endotracheal intubation; (3) Severe hepatic and renal insufficiency (alanine aminotransferase and aspartate aminotransferase exceeding 2 times the upper limit of normal, serum creatinine and urea nitrogen exceeding the upper limit of normal); (4) Preoperative active pulmonary infection (such as pneumonia, bronchitis, etc.), oxygenation disorders (PaO2/FiO2 < 300 mmHg), or pulmonary diseases such as pleural effusion and atelectasis; (5) Long-term smoking history (= 10 cigarettes per day for = 10 years) or long-term use of drugs affecting respiratory function and hemodynamics (such as ß-blockers, glucocorticoids, etc.); (6) Complicated with unstable underlying diseases such as diabetes mellitus, hypertension (poorly controlled blood pressure, systolic blood pressure = 160 mmHg or diastolic blood pressure = 100 mmHg), and coagulation disorders; (7) Conversion to open surgery during the operation, or operation time exceeding 3 hours (to avoid the interference of excessively long operation time on the research results); (8) Pregnant, lactating women, or women with plans for pregnancy; (9) Refusal to participate in this study, or inability to cooperate with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index (PaO2/FiO2);Pulmonary diffusion indices;Respiratory mechanics indices; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative pulmonary complications ; | — |
Countries
China
Contacts
Public ContactXuexin Chen
General Hospital of Ningxia Medical Univeristy
Outcome results
None listed