Osteoarthritis
Conditions
Interventions
Experimental Group A:BPL combined with CBI local infiltration and intra-articular injection of CBI. 20ml of BPL (266mg) + 1ml of CBI (dipropyl fluoromethane betamethasone 5mg and betamethasone phospha
Experimental Group B:BPL combined with CBI local infiltration and CBI intra-articular injection. 20ml of BPL (266mg) + 1ml of CBI (dipropyl fluoromethane betamethasone 5mg and betamethasone sodium pho
Experimental Group C:Local infiltration of BPL was performed. 20 ml of BPL (266 mg) was diluted with 60 ml of normal saline to a total volume of 80 ml. It was then injected around the knee joint in th
Control group:Local infiltration with ropivacaine was performed. 20 ml of ropivacaine was mixed with 60 ml of normal saline to dilute it to 80 ml. It was injected around the knee joint according to th
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients with primary knee osteoarthritis (OA), with conservative treatment ineffective for more than 6 months, severe joint wear, and Kellgren-Lawrence (KL) grade III–IV. 2.Scheduled to undergo primary unilateral total knee arthroplasty (TKA). 3.Age ranged from 18 to 80 years. 4.American Society of Anesthesiologists (ASA) physical status grade I–III. 5.Voluntarily participated in this study and provided written informed consent.
Exclusion criteria
Exclusion criteria: 1.History of adrenal insufficiency, adrenal injury, or adrenal surgery. 2.Cardiac insufficiency (heart failure), cardiac arrhythmia, or history of cardiac surgery. 3.History of hypersensitivity to BPL or CBI. 4.Presence of local infection focus, non-healed infection focus, or skin lesion at any body site. 5.Use of glucocorticoids within the past 3 months, or history of joint puncture or intra-articular drug injection. 6.Coagulation disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;Morphine and other opioid rescue analgesic doses;Fluctuation levels of the three major inflammatory markers ESR, CRP and IL6 ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fluctuation of skin temperature around the knee joint;Knee joint range of motion;Postoperative ambulation distance;Fluctuation of blood glucose;HSS score for joint function;WOMAC score for quality of life;Goodman Satisfaction Scale (GSS) ;Length of hospital stay (in hours);Occurrence of postoperative complications (nausea, vomiting, poor wound healing, wound infection, falls, nerve injury, DVT, quadriceps weakness, etc.); | — |
Countries
China
Contacts
Public ContactZeng Yi
West China Hospital, Sichuan University
Outcome results
None listed