Fever
Conditions
Interventions
The fever observation group:None
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Gender: No restrictions on gender; 3. Research participants who were admitted to Huashan Hospital from March 1, 2026 to January 31, 2028, and meet one of the following diagnoses: (1) Classic fever of unknown origin: Fever persists for more than 3 weeks, oral temperature exceeds 38.3 ? at least 3 times (or the temperature fluctuates by more than 1.2 ? within 1 day) after at least 1 week of outpatient or inpatient condition assessment, and the diagnosis remains unclear; (2) Fever of unknown origin for hospitalized participants: No fever at admission, and fever persists for more than 3 days after admission, oral temperature exceeds 38.3 ? at least 3 times or the temperature fluctuates by more than 1.2 ? within 1 day; (3) Fever of unknown origin with granulocyte deficiency: Absolute neutrophil count is less than 0.5*10^9/L; Fever persists for more than 3 days, oral temperature exceeds 38.3 ? at least 3 times or the temperature fluctuates by more than 1.2 ? within 1 day; The culture results of body fluid specimens are negative after more than 48 hours of incubation; 4. Routine clinical sample submission for targeted genomic sequencing and metagenomic sequencing (including blood, bronchoalveolar lavage fluid, cerebrospinal fluid, lung tissue, etc.); 5. Complete clinical data; 6. Understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The quality of the sample or sequencing data does not meet the standards; 2. Pregnant women; 3. Lack of key clinical information or dropouts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Copy number variation; | — |
Countries
China
Contacts
Public ContactJiachun Su
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed