Chronic pain after total knee arthroplasty
Conditions
Interventions
Observational cohort group:None
Sponsors
Handan Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosed with knee osteoarthritis and scheduled for primary unilateral total knee arthroplasty; 2. Age >= 18 years; 3. Able to provide preoperative fecal samples; 4. Able to complete postoperative follow-up; 5. Complete clinical data available
Exclusion criteria
Exclusion criteria: 1. Use of antibiotics, probiotics, prebiotics, or other drugs affecting gut microbiota within 4 weeks; 2. Presence of inflammatory bowel disease, severe infection, malignancy, autoimmune disease, or severe hepatic/renal dysfunction; 3. Previous revision or major lower limb surgery on the affected side; 4. Severe psychiatric or cognitive impairment preventing accurate pain assessment; 5. Postoperative mechanical complications such as infection, prosthesis loosening, instability, or fracture; 6. Inadequate sample quality or failed 16S/Raman testing; 7. Loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of chronic pain after total knee arthroplasty; | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee function scores (KSS or WOMAC);Preoperative gut microbiota features (16S rRNA sequencing);Preoperative Raman spectroscopy features; | — |
Countries
China
Contacts
Public ContactShihuan Chen
Handan Central Hospital
Outcome results
None listed