Pulmonary Arterial Hypertension, Atrial Septal Defect associated with Pulmonary Hypertension
Conditions
Interventions
Experimental group:Atrial septal defect repair surgery and pulmonary artery sympathetic denervation
Control group:Atrial Septal Defect Repair Surgery
Sponsors
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 65 years, with a clearly diagnosed atrial septal defect (defect diameter >5mm, including secundum type, primum type, or sinus venosus type) confirmed by transthoracic echocardiography or transesophageal echocardiography, accompanied by pulmonary hypertension (pulmonary artery systolic pressure >35 mmHg). Further screening by right heart catheterization confirms mean pulmonary artery pressure >20 mmHg and = 3 Wood units, requiring surgical treatment.
Exclusion criteria
Exclusion criteria: 1. Patients with other concomitant cardiopulmonary diseases (such as lung cancer, ventricular septal defect, patent ductus arteriosus, coronary artery disease and valvular disease, etc.); 2. Patients with significant organ dysfunction; 3. Patients with chronic diseases or those who refuse surgery; 4. Those for whom the researcher deems that surgical intervention would not benefit the patient or there are obvious contraindications to surgery; 5. Those who have undergone heart-lung surgery or received treatment with drugs that increase pulmonary pressure. 6. Patients with pulmonary hypertension caused by other etiologies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6-minute walk test;pulmonary systolic arterial hypertension; | — |
Countries
China
Contacts
Public ContactYuan Haiyun
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Outcome results
None listed