Alzheimer's Disease
Conditions
Interventions
TIS-? group:Temporal interference stimulation (TIS) will be delivered to the anterior part of the left hippocampus using carrier frequencies of 2000 Hz and 2005 Hz, producing a 5 Hz envelope frequency
TIS-? group:Temporal interference stimulation (TIS) will be delivered to the anterior part of the left hippocampus using carrier frequencies of 2000 Hz and 2040 Hz, producing a 40 Hz envelope frequenc
TIS-sham group:Temporal interference stimulation (TIS) will be delivered to the anterior part of the left hippocampus using carrier frequencies of 2000 Hz and 2000 Hz, producing a 0 Hz envelope freque
Sponsors
The Third Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=50 years at the time of voluntary participation and signing of the informed consent form. 2. Subject or informant reports progressive and gradual changes in memory function for >=3 months. 3. Diagnosed with Alzheimer's disease (AD) according to the National Institute on Aging–Alzheimer's Association (NIA-AA) 2024 diagnostic criteria. 4. Presence of mild cognitive impairment or mild-to-moderate dementia (10 <= MMSE <= 30 and CDR-GS = 0.5–2). 5. Sufficient literacy, auditory and visual abilities to complete neuropsychological testing. 6. If using cognitive-enhancing medications (e.g., donepezil, memantine), the dose must have been stable for at least 3 months prior to enrollment, and no dose adjustments will be made during the study period.
Exclusion criteria
Exclusion criteria: 1. Prior history of neurological disorders including brain tumor, traumatic brain injury, stroke, epilepsy, Parkinson's disease, or psychiatric disorders. 2. Prior history of metabolic diseases known to cause cognitive decline, including anemia, thyroid dysfunction, folate deficiency, vitamin B12 deficiency, etc. 3. History of alcohol or drug abuse within 2 years prior to screening. 4. Post-craniotomy or skull defect. 5. Presence of metallic or electronic device implants (e.g., cardiac pacemaker, cochlear implant, deep brain stimulator, aneurysm clip, internal fixation device following ventriculoperitoneal shunt, etc.). 6. Other serious diseases that may interfere with the study. 7. Concurrent participation in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Assessment Scale - Cognitive Subscale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination;Montreal Cognitive Assessment - Basic;Clinical Dementia Rating Scale;Neuropsychiatric Inventory;Functional Activities Questionnaire;Auditory Verbal Learning Test - Huashan Version;Pittsburgh Sleep Quality Index;Boston Naming Test;Digit Span Test;Electroencephalography;Resting-state Functional Magnetic Resonance Imaging;Diffusion Tensor Imaging;functional near-infrared spectroscopy; | — |
Countries
China
Contacts
Public ContactXiquan Hu
The Third Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed