Knee Osteoarthritis, KOA
Conditions
Interventions
Group E (Experimental Group):Loading dose: 0.2 mg/kg, intravenous slow bolus (>2 min). Maintenance dose: 0.125 mg/kg/h, continuous intravenous infusion.
Group C (Control Group):0.9% normal saline of equal volume and rate was given.
Sponsors
Jiangmen Wuyi Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 50 and 80 years, regardless of sex; 2. American Society of Anesthesiologists (ASA) physical status classification I–III; 3. Body Mass Index (BMI) ranging from 18 to 30 kg/m^2; 4. Clinical diagnosis of knee osteoarthritis, scheduled for elective unilateral total knee arthroplasty (TKA); 5. Normal cognitive function with no language or communication barriers, and ability to cooperate with Numerical Rating Scale (NRS) scoring and questionnaire completion; 6. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1.Known allergy or hypersensitivity to ketamine, esketamine, or opioids; 2.Severe mental disorders (e.g., schizophrenia, bipolar disorder) or a documented history of psychiatric illness; 3.History of substance abuse or chronic use of opioids 4.Severe uncontrolled hypertension (systolic blood pressure > 180 mmHg), intracranial hypertension, or glaucoma.; 5.Previous history of surgery or trauma to the ipsilateral knee joint; 6.Severe hepatic or renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Movement-evoked pain (NRS score) during active knee flexion at 24 h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Movement-evoked pain (NRS score) at 48 h postoperatively;Movement-evoked pain (NRS score) at 72 h postoperatively;Total opioid consumption within the first 48 hours postoperatively;Kinesiophobia at early postoperative stage (postoperative day 3), assessed by the TSK-11 score;Pain Catastrophizing (PCS score);Time to first ambulation;Incidence of Chronic Postoperative Pain (CPSP) at 3 months after surgery;Related adverse events (including nausea and vomiting, dizziness, and psychiatric symptoms, etc.); | — |
Countries
China
Contacts
Public ContactChao Wang
Jiangmen Wuyi Traditional Chinese Medicine Hospital
Outcome results
None listed