Ovarian Cancer
Conditions
Interventions
Experimental group:During chemotherapy, patients in the intervention group receive a 5-day monthly fasting-mimicking diet regimen: 1000 kcal on day 1 (10% protein, 56% fat, 34% carbohydrate), and 800
Control group:During chemotherapy, patients in the control group maintain a regular daily diet without specific restrictions on food type or caloric intake.
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 75 years inclusive. 2.No physical or mental conditions that would impede effective communication. 3.Conscious, alert, and cooperative. 4.Confirmed diagnosis of advanced ovarian cancer. 5.Scheduled to receive chemotherapy with paclitaxel at 170 mg/m² plus carboplatin at AUC = 5. 6.Chemotherapy-induced peripheral neuropathy (CIPN) diagnosed according to CIPNAT criteria, with all first four items answered "Yes". 7.Voluntary informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1.Diagnosed with a chronic disease that may cause peripheral neuropathy (e.g., diabetes mellitus). 2.Presence of neuropathic symptoms due to cervical or lumbar disc herniation. 3.Chronic alcohol consumption. 4.Current use of medications that may mask or induce neuropathic symptoms (e.g., opioids, ß-blockers, anticonvulsants, tricyclic antidepressants). 5.Previous treatment with neurotoxic chemotherapeutic agents (e.g., taxanes, vinca alkaloids, bortezomib). 6.Underwent major surgical intervention within the past one month. 7.Insufficient physical and cognitive capacity to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemotherapy-Induced Peripheral Neuropathy Assessment Tool Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 Score; | — |
Countries
China
Contacts
Public ContactWeng Meilin
Zhongshan Hospital, Fudan University
Outcome results
None listed