Opioid-Related Adverse Effects
Conditions
Interventions
Oliceridine group:Oliceridine was used during induction of general anesthesia and for postoperative analgesia.
hydromorphone group:Hydromorphone was used during induction of general anesthesia and for postoperative analgesia.
Sponsors
Shunde Hospital Guangzhou University of Chinese Medicine(ShunDe District Hospital of Chinese Medicine of Foshan City)
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing lumbar fusion surgery under general anesthesia with endotracheal intubation; 2.Aged 60–80 years, of either sex; 3.American Society of Anesthesiologists (ASA) physical status classification I–III; 4.No severe cardiac, pulmonary, hepatic, or renal dysfunction; 5.Voluntarily participating in this study and having signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe hepatic or renal dysfunction; 2. Patients with severe cardiac dysfunction; 3. Patients who have used analgesic drugs within 24 hours before surgery; 4. Patients with spinal tumors, tuberculosis, or other infectious conditions; 5. Patients with communication barriers, delirium, or those unlikely to comply with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale score;Postoperative opioid-related adverse events;Length of hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of rescue analgesia administrations;Satisfaction score with anesthesia; | — |
Countries
China
Contacts
Public ContactWeilin Huang
Shunde Hospital Guangzhou University of Chinese Medicine(ShunDe District Hospital of Chinese Medicine of Foshan City)
Outcome results
None listed