Helicobacter pylori infection
Conditions
Interventions
Intervention group:Vonoprazan and amoxicillin dual eradication regimen combined with Saccharomyces boulardii
Control group:Vonoprazan and amoxicillin dual eradication regimen
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 70 years old; 2.Treatment-naive patients with Helicobacter pylori infection confirmed by ¹³C urea breath test; 3.Alert and conscious with full capacity for independent behavior, capable of cooperating with the intervention; 4.Voluntarily agree to participate in this study and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Previous history of Helicobacter pylori eradication therapy; 2.Known allergy to any study medication, or presence of contraindications to eradication therapy; 3.Pregnant or breastfeeding women; 4.Recent use of medications that may affect the gut microbiota, such as antibiotics, probiotics, acid-suppressive drugs, etc; 5.Previous history of gastrointestinal surgery; 6.Severe comorbidities: serious diseases of the heart, lung, liver, kidney or other vital organs, or other conditions that may affect the study results; 7.Alcohol abusers or drug addicts; 8.Diseases affecting the primary outcome: diarrhea, constipation, abdominal pain, nausea, rash, peptic ulcer, inflammatory bowel disease, celiac disease, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal Symptom Rating Scale (GSRS) Score;Incidence of adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Quality;Depressive tendency;Nutritional status;Helicobacter pylori eradication rate; | — |
Countries
China
Contacts
Public ContactMa Yongchen
Peking University First Hospital
Outcome results
None listed