Intractable migraine
Conditions
Interventions
Fake stimulation group:Magnetic resonance guided multi-channel time-domain interference stimulation false stimulation
Real stimulus group:Magnetic resonance guided multi-channel time-domain interferometric stimulation
Sponsors
The First Affiliated Hospital of Bengbu Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Be clearly diagnosed as chronic migraine or episodic refractory migraine in accordance with the International Classification of Headache Disorders (ICHD-3); 2. Aged 18 to 65 years old; 3. Participate voluntarily and obtain informed consent from the subject or family members; 4. Able to understand written language and complete clinical scale scores. 5. Right-handed.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to MRI: pacemaker, deep brain stimulator, aneurysm clips, metal implants (except some titanium alloys) or any other metal foreign body unsuitable for MRI scanning; Suffering from claustrophobia. 2. Presence of contraindications to TIS, including intracranial implants (e.g., aneurysm clips, diverters, stimulators, cochlear implants, or electrodes); Any metal object in or near the head that cannot be safely removed; Use of medications that may interfere with the efficacy of TIS, such as barbiturates, benzodiazepines, and certain anticonvulsants; 3. Laboratory tests suggest impaired liver or renal function, or other important neurological or psychiatric diseases, such as severe cardiovascular and cerebrovascular diseases (such as unstable angina, recent stroke), epilepsy, brain tumors, history of major brain trauma, dementia, bipolar disorder or schizophrenia, etc. 4. Pregnant or lactating women. 5. Participated in other clinical trials within the past 3 months. 6. Recent history of drug or alcohol abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Headache frequency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Headache impact: using the Migraine Disability Assessment Scale (MIDAS);Pain severity rating: Visual Analogue Scale (VAS);Emotional state; | — |
Countries
China
Contacts
Public ContactYe Ming
The First Affiliated Hospital of Bengbu Medical University
Outcome results
None listed