Obesity, sarcopenia, sarcopenic obesity
Conditions
Interventions
Normal Control Group:None
Sarcopenia Group:None
Sarcopenic Obesity Group:None
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-65 years; 2.The patient is able to understand the study protocol and willing to participate in this study, providing written informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe liver and kidney diseases, including ALT or AST > 3 times the upper limit of normal, Child-Pugh class B-C liver function, eGFR < 30 mL/min/1.73m^2, or those requiring dialysis; 2. Severe respiratory diseases, including respiratory failure at rest, severe COPD (GOLD stage III-IV), uncontrolled asthma, or those requiring long-term home oxygen therapy; 3. Severe cardiovascular and cerebrovascular diseases, including NYHA class III-IV heart function, myocardial infarction or stroke within the past 6 months, uncontrolled hypertension (systolic blood pressure = 180 mmHg), or malignant arrhythmia; 4. Malignant tumors; 5. Acute or chronic infections; 6. Acute diabetic complications such as diabetic ketoacidosis, hyperosmolar coma, and lactic acidosis; 7. Diseases affecting motor function, such as Parkinson's disease, motor neuron disease, sequelae of stroke, and severe osteoarthritis; 8. Use of any medications or supplements that significantly affect body composition or athletic performance (only multivitamins are allowed), including glucocorticoids, sex hormones, thyroid hormones, growth hormones, antipsychotics, antidepressants, and glucose-lowering drugs such as SGLT2 inhibitors, thiazolidinediones, and GLP-1 receptor agonists; 9. Presence of metal stents, pacemakers, or other devices that interfere with body composition measurement; 10. Pregnant or lactating women; 11. Individuals unable to cooperate with the assessment of muscle function indices or body composition analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum HICA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid profiles(CHO?TG?LDL-c?HDL-c);Inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor alpha);Creatinine;Muscle function indicators;Body composition parameters(Whole body fat mass, appendicular skeletal muscle mass, skeletal muscle index, body fat percentage, visceral fat area);Demographic indicators including age, gender, height, weight, waist circumference, hip circumference, heart rate, blood pressure, body mass index (BMI);Fasting insulin;Fasting glcose;Liver function(ALTASTGGT); | — |
Countries
China
Contacts
Public ContactLiu Changqin
The First Affiliated Hospital of Xiamen University
Outcome results
None listed