acute lymphocytic leukemia
Conditions
Interventions
Case series:None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed patients with bone marrow morphological diagnosis of ALL and immunological typing of ALL; 2. Age range of 1 month to 18 years; 3. Patients receiving HD-MTX therapy for the prevention of extramedullary leukemia; 4. Monitoring of MTX plasma concentrations at 24,48, and 72 hours post-administration; 5. Complete baseline data on complete blood count (CBC) and liver/kidney function tests prior to HD-MTX therapy.
Exclusion criteria
Exclusion criteria: 1. Secondary to immunodeficiency disorders; 2. Severe acute infections prior to HD-MTX chemotherapy; 3. Mature B-cell ALL and mixed phenotype leukemia (excluding ALL with myeloid antigen expression); 4. Second malignancy or confirmed acute exacerbation of chronic leukemia; 5. Various forms of intramedullary or extramedullary relapse; 6. Missing key study indicators in IIH collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood drug concentration;adverse reaction; | — |
Countries
China
Contacts
Public ContactTu Yingqiu
The First Affiliated Hospital of Nanchang University
Outcome results
None listed