Sepsis with septic shock
Conditions
Interventions
Methylene Blue Group:None
Sponsors
The First Affiliated Hospital,Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age > 18 years; 2.Diagnosis of septic shock as defined by the Sepsis-3 criteria (suspected or confirmed infection, requiring norepinephrine to maintain MAP >= 65 mmHg or serum lactate > 2 mmol/L after adequate fluid resuscitation); 3.Receiving intravenous methylene blue infusion with a norepinephrine dose >= 0.25 µg/(kg·min) at the time of administration;
Exclusion criteria
Exclusion criteria: 1.Pregnancy or lactation; 2.Personal or family history of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency; 3.Known allergy to methylene blue; 4.Participation in another interventional clinical trial; 5.Any other condition deemed by the investigator to be inappropriate for participation in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diastolic Shock Index, DSI; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day vasopressor-free days;28-day all-cause mortality; | — |
Countries
China
Contacts
Public ContactSong Wenliang
The First Affiliated Hospital,Sun Yat-sen University
Outcome results
None listed