Various neurological and systemic diseases can lead to autonomic dysfunction, which in turn triggers a series of clinical symptoms. For example, patients with Parkinson's disease often experience autonomic dysfunctions such as constipation, urinary disturbances, and orthostatic hypotension
Conditions
Interventions
Sham Group:Sham transcutaneous auricular vagus nerve stimulation
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.age: 18–80 years; 2.presence of clinical symptoms related to autonomic dysfunction, including at least one of the following: palpitations, orthostatic intolerance, fatigue, sleep disturbances, gastrointestinal dysfunction, or chronic pain accompanied by signs of autonomic imbalance; 3.autonomic function assessment indicates functional abnormalities, such as reduced heart rate variability, abnormal tilt test results, or other objective or semi-objective evaluations supporting autonomic dysfunction; 4.voluntary acceptance of transauricular vagus nerve electrical stimulation treatment and signing of an informed consent form.
Exclusion criteria
Exclusion criteria: 1.individuals with unstable physical conditions, such as severe pulmonary and cardiac diseases, liver or kidney failure, or a history of malignant tumors; 2.those with implanted pacemakers, implantable cardioverter-defibrillators, or other internal electrical stimulation devices; 3.those with severe organic autonomic neuropathy who are unsuitable for neuroregulation therapy during the rehabilitation phase; 4.those with local infections, damage, or skin lesions on the auricle that prevent electrical stimulation; 5.individuals with severe mental disorders, cognitive impairments, or who cannot cooperate with treatment and assessment; 6.those who are pregnant or otherwise assessed as unsuitable for electrical stimulation therapy; 7.individuals with a heart rate below 60 beats per minute.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep Disorder Assessment;Pain Assessment;Emotion;Constipation Functional Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanism evaluation; | — |
Countries
China
Contacts
Public ContactPeijia Jing
West China Hospital of Sichuan University
Outcome results
None listed