Blood drug concentration
Conditions
Interventions
Group 1:Subarachnoid injection 0.75% bupivacaine 15mg (2ml) + fentanyl 50ug (1ml)
Sponsors
People's Hospital of Ningxia Hui Autonomous Region
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old, ASA grade II-III; 2. Unilateral total hip/knee arthroplasty is planned under subarachnoid anesthesia; 3. Normal spinal canal anatomy (L3-L4 intervertebral space width >= 0.5 cm), confirmed by lumbar X-ray; 4. Mild abnormal liver and kidney function can be included (ALT/AST <= 2 times the normal value, serum creatinine <= 178 µmol/L, urea nitrogen <= 14.3 mmol/L); 5. Clear consciousness and able to cooperate with clinical assessments such as anesthesia plane and pain score; 6. Sign the informed consent form and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: 1. Age 30 kg/m^2, combined with mental illness or cognitive impairment who cannot cooperate with the assessment; 6. Those who have a history of lumbar spine surgery, spinal canal tumors, or neurological diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial plasma concentrations of bupivacaine and fentanyl;Anesthesia plane indicators: time to formation of the anesthesia plane, highest level of blockade, duration of effective anesthesia plane;Motor block indicators: onset time of motor block, time to maximum motor block, Modified Bromage score at each time point; | — |
Countries
China
Contacts
Public ContactLi Hui
People's Hospital of Ningxia Hui Autonomous Region
Outcome results
None listed