Periodontitis
Conditions
Interventions
Control group:Hyaluronic acid gel without loading the exocrine body of dental follicle stem cells
Experimental group:Hyaluronic acid gel loaded with exocrine body of dental follicle stem cells
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The age range is from 18 to 60 years old, inclusive of the boundaries, regardless of gender. 2. The subjects meet the diagnostic criteria for periodontitis stage III/IV (International New Classification of Periodontal and Peri-implantitis Diseases in 2018). 3. The clinical probing depth of the tested teeth is >= 5mm and the radiographic examination reveals a subgingival pocket of >= 2mm, with a mobility of = 2mm. 4. The subjects have given informed consent, understand the purpose of this trial, and can cooperate with the trial requirements and undergo regular follow-up for at least 6 months after the treatment. 5. The subjects can achieve good self-plaque control, including correct brushing and proper use of dental floss, etc.
Exclusion criteria
Exclusion criteria: 1. Those with severe periodontal disease (alveolar bone resorption exceeding two-thirds of the tooth root length) or whose occlusal trauma affects the interpretation of the research results; 2. Those with a distance from the lowest point of the periodontal pocket beneath the tooth to the root apex 7.0% within 3 months before screening; 7. Smokers (smoking >= 10 cigarettes per day within 6 months before screening); 8. Those with uncontrollable systemic infections; 9. Those who, in the researcher's judgment, are not suitable to participate or have withdrawn the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement value of the periodontal clinical attachment level at the 6th month after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The positive rate of bleeding detected by probing at the 6th month after the operation;Improvement value of gum recession at the 6th month after surgery;The improvement of root bifurcation lesion grading at the 6th month after the surgery;The improvement in tooth looseness at the 6th month after the surgery;The depth of bone defect repair at the 6th month after the surgery;The increase in the area of keratinized gingiva at the 6th month after the surgery;The increase in the filling of the gingival papillae at the 6th month after the operation;Patient's subjective perception evaluation; | — |
Countries
China
Contacts
Public ContactJianhong Hou
The First People's Hospital of Yunnan Province
Outcome results
None listed