Depression disorder
Conditions
Interventions
Intervention group:Intermittent Theta-Burst Stimulation (iTBS)
Sponsors
Beijing Huilongguan Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for major depressive disorder or bipolar depressive episode according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 2.Aged >=18 years, with no restriction on sex; 3.A score of >=17 on the 17-item Hamilton Depression Rating Scale (HAMD-17); 4.Right-handed; normal vision or normal vision after correction; 5.On stable medication, with no changes throughout the intervention period (either medication-free or maintaining the same type and dosage of antidepressants); 6.Voluntarily participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Currently or previously diagnosed with other major psychiatric disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), excluding major depressive disorder or bipolar depressive episode (e.g., other psychotic disorders, substance-related and addictive disorders, substance/medication-induced psychotic disorders, neurodevelopmental disorders, or neurocognitive disorders); 2.Presence of serious physical illnesses at present that, in the investigator’s judgment, make the individual unsuitable for participation in this study; 3.Currently pregnant, within <=6 months postpartum, or breastfeeding; 4.Presence of major neurological disorders, or implantation of devices such as cardiac pacemakers or deep brain stimulation electrodes, rendering the individual unsuitable for receiving brain stimulation; 5.Individuals with a high current risk of suicide or those unable to cooperate with treatment and data collection; 6.Receipt of physical therapies such as ECT/MECT, VNS, or DBS within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale (HAMD) Score;Hamilton Anxiety Rating Scale (HAMA) Score;Self-Rating Anxiety Scale (SAS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Beck Depression Inventory (BDI) Score; | — |
Countries
China
Contacts
Public ContactZhiren Wang
Beijing Huilongguan Hospital Affiliated to Capital Medical University
Outcome results
None listed