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Safety and quality of recovery after bronchoscopy with esketamine and propofol in adults with predicted difficult Airways: a single-center, randomized, double-blind, controlled trial

Safety and quality of recovery after bronchoscopy with esketamine and propofol in adults with predicted difficult Airways: a single-center, randomized, double-blind, controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600123778
Enrollment
Unknown
Registered
2026-04-29
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoxemia during bronchoscopy

Interventions

Group S:Sufentanil 0.2ug/kg was given intravenously for 20s-30s during the induction period.
E group:During the induction period, 0.2 mg/kg of esketamine was given by slow intravenous injection for 20 s to 30 s.

Sponsors

Ganzhou People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.A clear record of "difficult intubation" or "difficult mask ventilation", a history of asthma, and a history of obstructive sleep apnea (OSA) in previous anesthesia records; 2.Positive on any of the following physical examinations: Mallampati III-IV, mouth opening < 3 cm, mento-hyoid distance/mandibular retrusion,Limited mandibular protrusion, limited neck mobility, snoring, increased neck circumference (e.g. BMI = 30 and neck circumference = 40 cm), tongue hypertrophy, edentulous; 3.Cervical and facial anatomical abnormalities/airway lesions (airway tumors, airway stenosis, radiotherapy scars, etc.); 4.other inclusion: age = 18 years and < 75 years, American Society of Anesthesiologists (ASA) grade I ~ III, electronic/fiberoptic bronchoscopy is to be performed, sedation/anesthesia cooperation is required, and informed consent is signed;

Exclusion criteria

Exclusion criteria: 1.Patients who need urgent airway establishment; 2.Patients with "catastrophic upper respiratory tract pathology" (such as huge laryngeal mass with resting laryngeal stridor, severe tracheal stenosis 40 kg/m ²) and severe OSA syndrome; 5.Patients unable to provide informed consent; 6.Patients with operation duration > 60 min.

Design outcomes

Primary

MeasureTime frame
Hypoxemia;

Countries

China

Contacts

Public ContactHuang Guiming

Ganzhou People's Hospital

hgm0911@126.com+86 10 5889062

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026