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Fundamental Research on Metabolomics-Based Response Variability to Tocilizumab Treatment in Rheumatoid Arthritis

Fundamental Research on Metabolomics-Based Response Variability to Tocilizumab Treatment in Rheumatoid Arthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600123770
Enrollment
Unknown
Registered
2026-04-29
Start date
2023-07-27
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis

Interventions

Control group:None

Sponsors

Sichuan Provincial Orthopaedic Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. All patients met the diagnostic criteria for rheumatoid arthritis (American College of Rheumatology, ACR) and were clearly diagnosed with rheumatoid arthritis. Diagnostic basis: The diagnosis of RA must meet the following clinical features: (1) Inflammatory arthritis involving three or more joints; (2) Positive rheumatoid factor (RF) and/or anti-citrullinated peptide/protein antibodies (ACPA), such as anti-cyclic citrullinated peptide antibody (anti-CCP) testing; (3) Elevated levels of C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR); (4) Exclusion of diseases with similar clinical features, especially psoriatic arthritis, acute viral polyarthritis, polyarticular gout or calcium pyrophosphate deposition disease, and systemic lupus erythematosus (SLE); (5) Symptoms lasting more than six weeks; 2. The healthy control group was selected from individuals undergoing health examinations during the same period, with clinical laboratory tests excluding other immune system diseases. 3. Complete clinical data were available for all study subjects, and they voluntarily participated in this study.

Exclusion criteria

Exclusion criteria: 1.Other autoimmune diseases;

Design outcomes

Primary

MeasureTime frame
Biomarker;

Secondary

MeasureTime frame
Chronic diseases;IL-6;BMI;History of smoking, alcohol consumption, medication use, etc.;Gender;Blood pressure;Age;

Countries

China

Contacts

Public ContactQin Wang

Sichuan Provincial Orthopaedic Hospital

314306221@qq.com+86 28 87034228

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026