Overweight and Obesity
Conditions
Interventions
Overweight/Obesity Group:NA
Sponsors
The Second Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–65 years with ASA physical status I–III; 2. Body Mass Index (BMI) meeting the following grouping criteria: Normal control group (18.5 = 24.0 kg/m²); 3. Voluntary participation with written informed consent approved by the Ethics Committee; 4. No cognitive or verbal communication impairments, with the ability to fully cooperate with the study procedures; 5. Scheduled for elective surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Severe organ dysfunction, including severe hepatic or renal insufficiency, unstable coronary syndrome, uncontrolled hypertension, and other severe cardiovascular diseases; 2. History of chronic pain or long-term use of opioids/sedatives; preoperative use of potent CYP3A inhibitors or inducers; 3. Contraindications to body composition measurement via Bioelectrical Impedance Analysis (BIA), including abdominal wall stoma, massive ascites, limb amputation/absence, and presence of cardiac pacemakers or implantable cardioverter-defibrillators (ICDs); 4. Women who were pregnant or breastfeeding were excluded from the study; 5. Known hypersensitivity or allergy to study medications; 6. Any other condition deemed by the investigator to make the patient unsuitable for participation, including but not limited to severe psychiatric disorders or legal restrictions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic Parameters of Sufentanil (e.g., Clearance, Volume of Distribution, Half-life);The occurrence rate of adverse events during surgery and the postoperative period; | — |
Secondary
| Measure | Time frame |
|---|---|
| ody Composition Parameters (Visceral Fat Area, Waist Circumference, Muscle Mass, Fat Mass);Anesthesia Recovery Time and Extubation Time;Postoperative Rescue Analgesic Consumption; | — |
Countries
China
Contacts
Public ContactLi Ting
The Second Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed