Alzheimers disease
Conditions
Interventions
Sham stimulation group:Administer sham stimulation to the patient
20Hz-DLPFC group:20Hz Transcranial Magnetic Stimulation Targeting the DLPFC
iTBS-DLPFC group:Intracranial Transcranial Brain Stimulation Targeting the DLPFC
20Hz-Personalized Target group:20Hz transcranial magnetic stimulation targeting personalized sites determined based on network connectivity
Sponsors
Huanhu Hospital, Tianjin, China
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 50 - 85 years old; meets the diagnostic criteria for AD proposed by NIA-AA; 2. The patient's Mini-Mental State Examination (MMSE) score is between 10 and 27; 3. Mild to moderate AD patients, i.e., Clinical Dementia Rating (CDR) <= 2 points; 4. The patient and their family members have the capacity for civil conduct, and are capable of understanding and signing the consent form.
Exclusion criteria
Exclusion criteria: 1. Has a history of epilepsy or other neurological disorders; 2. Has severe depression with a score of >20 on the 24-item Hamilton Depression Rating Scale (Hamilton Depression Scale, HAMD); 3. Has visual or auditory impairment; 4. Has any serious chronic systemic disease history, brain injury history, history of alcohol or drug abuse; 5. Has any contraindications for TMS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE and MoCA scales; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram (EEG) indicators;Nuclear magnetic indicators;Blood biomarker; | — |
Countries
China
Contacts
Public ContactPan Wang
Tianjin Huanhu Hospital
Outcome results
None listed