Randomized Controlled Clinical Study on Single-Dose Esketamine Administration During Induction for Preventing Intraoperative Penile Erection

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600123737

Enrollment

Unknown

Registered

2026-04-29

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

priapism

Interventions

experimental group:0.5mg/kg esketamine

control group:None

Eligibility

Sex/Gender

Male

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Male patients aged 20-50 (as IPE is most prominent in this age group, over 70% of patients with IPE are under 50 years old) 2. Patients scheduled for elective urological surgeries and requiring perineal surgical disinfection

Exclusion criteria

Exclusion criteria: 1. Allergic to the experimental drug 2. Mental disorder 3. Preoperative coexisting central nervous system disease 4. Preoperative coexisting glaucoma 5. Heart dysfunction 6. Unplanned admission to ICU 7. Poorly controlled hypertension 8. Use of vasoactive drugs before perineal surgical disinfection 9. Erectile dysfunction of the penis 10. Refusal to participate in this experiment

Design outcomes

Primary

Measure	Time frame
Erection Hardness Score ;	—

Secondary

Measure	Time frame
Ureteral tolerance score;extubation time;PACU stay time;The number of times of epinephrine rescue;	—

Countries

China

Contacts

Public ContactYanyan Sun

Shenzhen University General Hospital

yysun@szu.edu.cn+86 755 2183 9999

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026