Rheumatoid Arthritis
Conditions
Interventions
Gold Standard:Standard contrast-enhanced Magnetic Resonance Imaging (CEMRI)
Index test:Diffusion-weighted imaging and unenhanced T1-weighted imaging fusion image (DFT)
Sponsors
Shanghai Oriental Hospital
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 16 years; 2. Presence of at least one clinically swollen wrist or metacarpophalangeal (MCP) joint at enrolment; 3. Receiving stable treatment with conventional disease-modifying antirheumatic drugs (DMARDs), biologics, or glucocorticoids (with no changes within one week prior to MRI and clinical assessment).
Exclusion criteria
Exclusion criteria: 1. Contraindications to MRI examination (e.g., implant incompatibility, severe claustrophobia); 2. Pregnancy; 3. Severe renal impairment (estimated glomerular filtration rate < 30 mL/min/1.73 m^2); 4. Prior wrist or hand surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Synovitis;Sensitivity of DFT and CE-MRI for diagnostic performance;Specificity of DFT and CE-MRI for diagnostic performance;Accuracy of DFT and CE-MRI for diagnostic performance;Contrast-to-Noise Ratio (CNR) of DFT and CE-MRI images;Signal-to-Noise Ratio (SNR) of DFT and CE-MRI images;Bone-Synovial Fluid Signal Ratio (SBR) of DFT and CE-MRI images;Contrast of DFT and CE-MRI images;Clarity of DFT and CE-MRI images; | — |
Countries
China
Contacts
Public ContactLu Qing
Shanghai Oriental Hospital
Outcome results
None listed