choledocholithiasis , Bile duct stenosis
Conditions
Interventions
Rimazolen combined with hydrocodone (R) group:Intravenous injection of 0.1 mg/kg hydrocodone (injection time 30 seconds), followed by intravenous injection of 0.15-0.3 mg/kg remifentanil 3 minutes lat
Propofol combined with sufentanil (P) group:Intravenous injection of sufentanil at a dose of 0.1 µg/kg (pushed over 30 seconds), followed by intravenous injection of propofol at a dose of 1-2 mg/kg 3
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for ERCP (common bile duct stones, biliary stricture, cholangiocarcinoma, etc.); 2. Age: 65–85 years; 3. American Society of Anesthesiologists (ASA) classification: I–III; 4. Agree to and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Body weight 40 kg/m^2; 2. History of anticipated difficult airway or severe respiratory system disease: acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, sleep apnea syndrome (STOP-Bang score >=5), etc.; 3. History of uncontrolled hypertension (or admission systolic blood pressure >=180 mmHg or diastolic blood pressure >=110 mmHg); 4. Obvious clinical symptoms of liver, kidney, hematologic, nervous system, or endocrine system diseases; 5. Chronic pain with long-term use of analgesics or psychotropic drugs; 6. Mental illness with a history of taking monoamine oxidase inhibitors or antidepressants within 15 days; 7. Allergy to any drugs involved in the study; 8. Participation in other drug clinical trials within the past three months; 9. Hearing, vision, or speech impairment that hinders communication; 10. Expected ERCP procedure duration >2 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate;Postoperative recovery time;Postoperative nausea and vomiting score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypoxemia;Cardiovascular adverse events; | — |
Countries
China
Contacts
Public ContactLining Huang
The Second Hospital of Hebei Medical University
Outcome results
None listed