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The Impact of Splenectomy on Debridement Efficacy, Perioperative Recovery, and Prognosis in Patients with Acute Necrotizing Pancreatitis Complicated by Pancreatic Sinistral Portal Hypertension

The Impact of Splenectomy on Debridement Efficacy, Perioperative Recovery, and Prognosis in Patients with Acute Necrotizing Pancreatitis Complicated by Pancreatic Sinistral Portal Hypertension

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600123713
Enrollment
Unknown
Registered
2026-04-29
Start date
2025-04-28
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Necrotic Pancreatitis

Interventions

Control Group:Open debridement
Splenectomy group:Open debridement, distal pancreatectomy, and splenectomy

Sponsors

The First Affiliated Hospital of Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Age between 18 and 75 years; 2.Acute necrotic pancreatitis complicated by pancreatic sinistral portal hypertension; 3.Patients undergoing open debridement for infected pancreatic necrosis;

Exclusion criteria

Exclusion criteria: 1.Patients with pre-existing heart, lung, liver, kidney, or other organ failure prior to acute pancreatitis (AP); 2.Patients with pre-existing conditions such as cirrhosis that may lead to portal hypertension prior to AP; 3.Patients with pre-existing hematological diseases prior to AP; 4.Patients undergoing laparoscopic or nephroscopic debridement;

Design outcomes

Primary

MeasureTime frame
Length of hospital stay after debridement;Degree of pancreatic sinistral portal hypertension;

Secondary

MeasureTime frame
Platelet number after debridement;Number of unplanned operations after the first debridement;

Countries

China

Contacts

Public ContactTingbo Liang

The First Affiliated Hospital of Zhejiang University School of Medicine

liangtingbo@zju.edu.cn+86 13666676128

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026