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Study on the efficacy and safety of metronidazole fumarate for postoperative patient-controlled analgesia after thoracoscopy

Study on the efficacy and safety of metronidazole fumarate for postoperative patient-controlled analgesia after thoracoscopy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600123707
Enrollment
Unknown
Registered
2026-04-29
Start date
2026-04-29
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain

Interventions

Sufentanil analgesia pump group (control group):Administer routine postoperative analgesic medication
Taijilide analgesia pump group (experimental group):Administer Taijilide as postoperative analgesic medication

Sponsors

chongqing university cancer hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18 - 75 years old; 2. ASA classification: I - III grade; 3. Surgical type: Patients undergoing elective laparoscopic thoracic surgery; 4. Preoperative health condition: No use of opioid drugs or with a history of discontinuation for more than one month.

Exclusion criteria

Exclusion criteria: 1. Allergic to opioids or with a history of severe adverse reactions; 2. Having moderate to severe liver or kidney dysfunction (ALT, AST, creatinine more than twice the normal value); 3. Mental or psychological disorders: including severe anxiety disorder or depression; 4. Having a history of opioid dependence or abuse in the past; 5. Pregnant or lactating women; 6. Patients participating in other interventional trials simultaneously; 7. Patients who were converted to open chest surgery due to surgical needs during the operation; 8. Patients with low oxygen saturation and asthma.

Design outcomes

Primary

MeasureTime frame
The incidence rate of chronic pain within 6 months;

Secondary

MeasureTime frame
Perioperative complications: incidence of itching, nausea, vomiting, and hypoxemia (SpO2<90%) during the intravenous analgesia pump period (48 hours)?Adverse reactions: 1. Dizziness 2. Nightmares or h;The frequency of use of remedial analgesics, the number of effective presses of the analgesic pump, and the time of the first press.;

Countries

China

Contacts

Public ContactQi Chen

chongqing university cancer hospital

mozzie0518@cqu.edu.cn+86 23 6507 5688

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026