cervical cancer
Conditions
Interventions
transvaginal laparoscopic surgery, vNOTES:None
transabdominal laparoscopic surgery, LPS:None
Sponsors
Chengdu Women's and Children's Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Female patients aged 18 to 75 years; 2.Meeting the aforementioned pathological diagnosis and clinical staging criteria of FIGO 2018 Stage ?A1–?A2; 3.Undergoing radical hysterectomy plus pelvic lymphadenectomy / sentinel lymph node dissection via either vNOTES or LPS approach, with strict adherence to the modified tumor-free technique during surgery; 4.Postoperative pathology confirming high-risk or intermediate-risk factors indicating the need for postoperative adjuvant radiotherapy; 5.ECOG performance status score of 0–1; 6.Laboratory examinations including hepatic and renal function, routine blood test, and coagulation function meeting the criteria for radiotherapy and chemotherapy, with no contraindications to radiotherapy and chemotherapy; 7.Being able to cooperate in completing multimodal imaging examinations and follow-up for up to 5 years; 8.Voluntarily signing the informed consent form, understanding the study content and agreeing to cooperate.
Exclusion criteria
Exclusion criteria: 1.Complicated with other malignant tumors, or with a history of previous pelvic radiotherapy; 2.Undergoing open surgery rather than vNOTES or LPS approach; 3.Presence of severe pelvic adhesions, pelvic infection, intestinal obstruction, or other contraindications to radiotherapy; 4.ECOG score = 2, unable to tolerate surgery or postoperative chemoradiotherapy; 5.Abnormal results of hepatic and renal function, routine blood test, or other indicators that do not meet the requirements for chemoradiotherapy; 6.Pregnant or lactating females; 7.Suffering from mental illness, cognitive impairment, etc., unable to cooperate with examinations and follow-up; 8.Refusing to sign the informed consent form or declining to participate in study follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of grade =2 late toxicities at 3 years; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival, OS;Disease-Free Survival, DFS;Acute toxicity incidence;Quality of life (QoL) score; | — |
Countries
China
Contacts
Public ContactYonghong Lin
Chengdu Women's and Children's Central Hospital
Outcome results
None listed