Thyroid eye disease
Conditions
Interventions
Sponsors
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: TED patients: Newly diagnosed with thyroid eye disease (TED) within the past 12 months; age >= 18 years; complete thyroid function tests (T3, T4, thyroid-stimulating hormone (TSH), thyroid receptor antibodies (TRAb)) within 1 week after enrollment. Healthy controls (HC): Age >= 18 years; no history of thyroid disease or thyroid eye disease; no prior orbital/ocular inflammatory diseases; normal thyroid function (TSH within the reference range in the past 3 months or at the time of enrollment).
Exclusion criteria
Exclusion criteria: TED patients: history of autoimmune diseases; chronic infections; ocular interventions; recent immunosuppressive treatments or ocular surgery; active infections or trauma affecting ocular assessments. HC: any diagnosed autoimmune, inflammatory, endocrine (thyroid) disorder, or chronic infection; current or recent (past 3 months) systemic corticosteroids or immunomodulatory/immunosuppressive therapy; ocular surgery or significant ocular disease in the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood mononuclear cell (PBMC) immune cell subset frequencies (multiparameter flow cytometry); | — |
Countries
China
Contacts
Public ContactDU Lin
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong
Outcome results
None listed