Parathyroid Adenoma
Conditions
Interventions
Control group (parathyroid adenoma / adrenocortical adenoma):None
Experimental group (parathyroid carcinoma / adrenocortical carcinoma):None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. All cases were surgically resected parathyroid or adrenocortical tumor tissues, with definitive postoperative pathological diagnoses serving as the grouping criteria. 2.(2) Complete clinicopathological information was available for all cases. 3.(3) Samples were formalin-fixed paraffin-embedded (FFPE) tissues, with quality sufficient for proteomics and other analyses. 4.(4) All subjects were enrolled consecutively. 5.(5) All subjects agreed to participate in the study and signed informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Cases with uncertain pathological diagnosis or inability to distinguish between benign and malignant tumors, and cases related to familial endocrine tumor syndromes; 2. Parathyroid hyperplasia and adrenal cortical hyperplasia; 3. Severe tissue autolysis or RNA/DNA degradation; 4. Patients with previous or concurrent malignant tumors in other organs; 5. Samples from patients who have previously received preoperative radiotherapy, chemotherapy, targeted therapy, or embolization treatment that may alter tumor biological characteristics; 6. Individuals who refuse to participate in this trial or refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of candidate biomarkers in tissue samples; | — |
Countries
China
Contacts
Public ContactXiu Nie
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed