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Microcirculation Typing and Vascular Endothelial Glycocalyx Injury in Septic Shock: Associations with Organ Dysfunction and Prognosis – A Prospective Observational Cohort Study

Microcirculation Typing and Vascular Endothelial Glycocalyx Injury in Septic Shock: Associations with Organ Dysfunction and Prognosis – A Prospective Observational Cohort Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600123647
Enrollment
Unknown
Registered
2026-04-28
Start date
2026-05-01
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis shock

Interventions

Case group:NA

Sponsors

General Hospital of Ningxia Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years; 2. Meets Sepsis-3 septic shock diagnosis; 3. The first microcirculation monitoring and the first blood sample collection can be completed within 6 hours after ICU admission or after clear onset of shock; 4. The patient or legal representative signs the informed consent

Exclusion criteria

Exclusion criteria: 1. Pregnancy; 2. Expected death within 24 hours or withdrawal of treatment; 3. Severe oral mucosal damage/unable to perform sublingual monitoring; 4. End-stage condition caused by long-term immunosuppression; 5. Complicated by non-infectious shock requiring immediate surgical hemostasis

Design outcomes

Primary

MeasureTime frame
syndecan-1;Ang-2;Hyaluronan;Heparan Sulfate;—

Countries

China

Contacts

Public ContactXiaohong Wang

General Hospital of Ningxia Medical University

wxhhelen2005@sina.com+86 189 0956 4356

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026