General anesthesia
Conditions
Interventions
Observation group (after the start of the administration of sedative drugs, brain electrical signals were collected in both the awake and anesthetized states (CSI: 40-60) respectively):None
Sponsors
Dongguan People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age: >18 years old adult; 2. American Association of Anesthesiologists (ASA) Grade I-II (see Schedule 1 for ASA classification details); 3. Patients undergoing laparoscopic surgery under general anesthesia should be expected to have an operation time of more than 1 hour and less than 3 hours; 4. 45 kg < weight <100kg, and 18 kg/m^2 <=BMI <=30 kg/m^2; 5. The patient can understand and agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Preoperative complicated diseases that seriously affect the function of main organs: Cardiovascular system (including, but not limited to, a history of myocardial infarction or unstable angina within the previous 6 months, or a history of severe arrhythmias such as atrioventricular block of degree II or higher, Or history of NYHA class II and above), liver (aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >=1.5×ULN and/or total bilirubin (TBIL) >=1.5×ULN), kidney (serum creatinine (Cr) >=1.5 times upper limit of normal), or severe systemic Disease, For example, poorly controlled diabetes (HbA1c>9%), abnormal coagulation (prothrombin time (PT) prolongation exceeding 3 seconds and/or activated partial thromboplastin time (APTT) prolongation exceeding 10 seconds), hypertension (subjects who did not receive regular antihypertensive treatment or whose blood pressure was poorly controlled (subjects who sat up during screening) Systolic blood pressure >=160mmHg or =100mmHg or <=60mmHg during screening excluding abnormalities during anesthesia and surgery); 2. Preoperative mental illness, such as schizophrenia, severe depression, etc. 3. Preoperative central nervous system diseases (such as epilepsy, brain tumor, brain trauma, etc.); 4. Taking drugs that affect brain electrical activity (such as antiepileptic drugs, sedatives, antidepressants, etc.) within two weeks before surgery; 5. Have a history of severe allergy to anesthetic drugs or other medical history affecting the safety of anesthesia; 6. Pregnant or lactating women; 7. A history of drug use and/or alcohol abuse within 1 year before surgery, with an average daily drinking of more than 15g (15g of alcohol is equivalent to 450mL of beer or 150mL of wine or 50mL of light liquor); 8. Patients were unable to understand and sign the informed consent form due to language disorder, cognitive impairment or other reasons, or were unable to complete the relevant EEG data collection and monitoring.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Normaolization Symbol Transfer Entroy;Phase-amplitude coupling; | — |
Secondary
| Measure | Time frame |
|---|---|
| Target plasma concentration of sedatives; | — |
Countries
China
Contacts
Public ContactXie Haihui
Dongguan People's Hospital
Outcome results
None listed