inflammatory bowel disease (IBD)
Conditions
Interventions
Inflammatory tissue group:None
Non-inflammatory tissue group:None
Sponsors
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 75 years; 2.a definitive diagnosis of Crohn’s disease (CD) or ulcerative colitis (UC) established according to clinical, endoscopic, and histopathological criteria; 3.collection of paired, qualified intestinal mucosal tissue samples from both inflamed and non-inflamed regions during a single colonoscopic examination, with samples preserved in the institutional biobank; 4.availability of traceable, anonymized basic clinical information.
Exclusion criteria
Exclusion criteria: 1.Poor tissue sample quality precluding proteomic analysis (e.g., RNA degradation or insufficient protein abundance); 2.inability to definitively confirm paired “inflamed–non-inflamed” tissue relationships; 3.presence of concomitant intestinal malignancies, infectious enteric diseases, or other non–IBD-related gastrointestinal disorders; 4.receipt of specific treatments prior to sampling that could substantially alter intestinal protein expression.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expression levels of MAPK signaling pathway proteins in the peripheral blood of IBD patients;The expression levels of MAPK signaling pathway proteins in the feces of IBD patients;The expression levels of MAPK signaling pathway proteins in the urine of IBD patients;The expression levels of MAPK signaling pathway proteins in the inflammatory and non-inflammatory areas of the intestinal mucosa tissues of IBD patients; | — |
Countries
China
Contacts
Public ContactLei Wang
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed